Reticuloendothelial System Phagocytic Function in Patients with Hodgkin's Disease*

Reticuloendothelial system phagocytic function in patients with Hodgkin's disease.

Phagocytic function of the reticuloendothelial system as measured by the clearance of (125)I-labeled aggregated human serum albumin (AA) was studied in patients with Hodgkin's disease. Each more advanced stage of the disease was associated with more rapid clearance of the AA. Production of remission by radiation therapy or by chemotherapy was associated in some patients with slowing of the clea...

Study of reticuloendothelial phagocytic capacity in patients with cholestasis.

The phagocytic capacity of the reticuloendothelial system was studied by the clearance from the plasma of microaggregated iodinated human serum albumin. About half of the patients with cholestasis showed impaired Kupffer-cell phagocytosis. The finding may be relevant to the occurrence of surgical complications in patients with obstructive jaundice.

Reticuloendothelial phagocytic function in patients with leukemia, lymphoma and multiple myeloma.

Function of the Reticuloendothelial System

Reticuloendothelial clearance of carbon particles is inhibited by injection of heat-aggregated albumin. The possibility that this inhibition might involve a serum component has been explored. Evidence that such a serum factor does participate in carbon clearance inhibition by heat-aggregated albumin derives from the fact that prior treatment of the carbon with homologous serum eliminates the bl...

Studies of the reticuloendothelial system (RES). II. Changes in the phagocytic capacity of the RES in patients with certain infections.

In our previous communication (1), we have presented data indicating that the phagocytic capacity of the reticuloendothelial system (RES) can be determined by measuring the rate of disappearance of various doses of radioisotopically labeled aggregated albumin particles from the circulation. Since our results followed the mathematical model suggested first by Michaelis and Menten in their studie...